G.I. Joe movie. Though I'm not particularly crazy about Cobra-La and Cobra's mystical origins, the rest of the movie is some of the best 'Joe animation we've ever gotten, and the Commander's betrayal and disfigurement has always stuck with me. I think in my Joe-verse, maybe it's the rest of experimentation with Compound Z rather than the mutation spores of Cobra-La, and I'm thinking I might have to do a few more stages of his transformation, but I'm pretty happy with how he looks!
ASM Lizard - Full figure (I used 2 of his skinnier forearms, moving the thumb on one to make it a left hand)